Literature review granulomatous mastitis
From: George S.
Category: senior thesis
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Background: Idiopathic granulomatous mastitis IGM is a rare chronic inflammatory disease. Because of obscure etiology and diagnosis, its management remains a challenge. Rareness and varied presentation of IGM makes it difficult to standardize treatment protocol. The aim of this study was to analyze the clinical presentations, imaging findings, clinical course, and management of patients who were treated for IGM. Patients and Methods: In this study, a retrospective review of 15 patients with IGM between January and December was performed based on clinical, radiological, and pathological findings; follow-up information and recurrence were obtained from records. Results: The median age of presentation was 30 years age range: 24—
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Granulomatous mastitis can be divided into idiopathic granulomatous mastitis also known as granular lobular mastitis  and granulomatous mastitis occurring as a rare secondary complication of a great variety of other conditions such as tuberculosis and other infections, sarcoidosis and granulomatosis with polyangiitis. Special forms of granulomatous mastitis occur as complication of diabetes. Some cases are due to silicone injection Silicone-induced granulomatous inflammation or other foreign body reactions. Idiopathic granulomatous mastitis IGM is defined as granulomatous mastitis without any other attributable cause such as those above mentioned. It occurs on average two years and almost exclusively up to six years after pregnancy, usual age range is 17 to 42 years. Some cases have been reported that were related to drug induced hyperprolactinemia.
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No document with DOI "10.1.1.1022.6867"
Idiopathic granulomatous mastitis IGM is an uncommon benign disorder of the breast that can mimic two frequent breast disorders, breast carcinoma and breast abscess. In this report, we present two patients seen in a community teaching hospital over a period of one year, diagnosed with IGM after histological evaluation. One patient responded well to immunosuppressive therapy, but the second patient required bilateral mastectomy due to the severe and recurrent nature of the disease. IGM is a disorder that should be considered in the evaluation of women who present with painful breast disease.
Supplemental studies Infectious disease stains Acid fast and fungal stains must be negative Differential Diagnosis Granulomatous infection Sarcoidosis Mammary duct ectasia Puerperal mastitis Fungal and acid fast infections must be ruled out by stains and cultures. Nearly always occurs after pregnancy Mean interval 2 years Rare associations reported Oral contraceptive use Systemic lupus erythematosus Hyperprolactinemia Erythema nodosum Hard mass Usually not subareolar Treatment may be excision or steroids May recur following excision Lists Inflammatory and Infectious Breast Lesions Granulomatous lobular mastitis Mammary duct ectasia Puerperal mastitis Specific infectious processes Bacteria Bartonella henselae cat scratch disease Corynebacteria Fungi Actinomycosis Blastomycosis Cryptococcosis Histoplasmosis Mycobacterium tuberculosis Vasculitis Giant cell arteritis Polyarteritis nodosum Wegener granulomatosis Bibliography Rosen PP, Oberman HA. Granulomatous lobular mastitis. J Clin Pathol. The value of cytology in granulomatous mastitis: a report of 16 cases from Malaysia.